Synthesis of novel 2-thioxo-4-imidazolidinone derivatives and evaluation of their antibacterial, and antifungal activities

The infectious diseases caused by antimicrobials pathogens are difficult, harmful, and sometimes impossible to treat. Therefore, design new drugs treat antimicrobial infections is the biggest challenge for modern medicine. 2-Thioxo-4-imidazolidinone used synthesis of a wide variety substituted imidazolidinone derivatives. In this study, we designing eight novel compounds derived 2-thioxo-4-imidazolidinones (5a-h). preparation was in two steps via Micheal addition phenyl hydrazide (2a), 4-methyl 2b on N-substituted maleimides 1a-d ethanol, second step reaction maleimide derivatives with cyclohexyl isothiocyanate 4 acetonitrile. chemical structures were identified using FT-IR, 1H-NMR, 13C-NMR, mass spectra, as well melting point. antibacterial antifungal evaluation carried out target their activities. Compound N-(5-(2-((4-chlorophenyl)amino)-2-oxoethyl)-3-cyclohexyl-4-oxo-2-thioxoimidazolidin-1-yl) benzamide (5b) exhibited activity toward Staphylococcus aureus Pseudomonas aeruginosa equal minimum inhibitory concentration (MIC) values 25 mg/mL. Compounds N-(3-cyclohexyl-4-oxo-5-(2-oxo-2-(phenylamino)ethyl)-2-thioxoimidazolidin-1-yl) (5a), (5b), N-(5-(2-((4-bromophenyl)amino)-2-oxoethyl)-3-cyclohexyl-4-oxo-2-thioxo imidazolidin-1-yl) (5c), N-(3-cyclohexyl-4-oxo-5-(2-oxo-2-(phenylamino)ethyl)-2-thioxoimidazolidin-1-yl)-4-methyl (5e) Candida albicans, while all Aspergillus niger except compound 5h, various MIC values. conclusion, results demonstrate that have promise agents. Moreover, 5b could develop an agent.